Study at TCU


Official Title Associate Professor
Affiliation Applied Chemistry
Profile Sho Hideshima received the B.S. degree and Ph.D. degree in engineering both from Waseda University, Japan in 2004 and 2011, respectively. After working as a jounior researcher (assistant professor) for Research Organization for Nano & life Innovation at Waseda University, he became an associate professor at Shinshu University. From 2021, he is an associate professor at Tokyo City University. His research interests include nanomaterials and interfaces for biosensing and energy devices.
Research Field(Keyword & Summary)
  1. (1) Nanomaterial-based electrochemical biosensors

    Two dimensional nanosheets possess specific characteristics in high surface area and electronic conductivity comparable to typical metallic materials. However, when fabricating nanosheet electrodes for electrochemical applications, due to the highly anisotropic nature, the nanosheet tends to re-stack and generally aligns horizontally with respect to the current collector. Such electrodes suffer from low active surface area and slow kinetics owing to the poor diffusivity of the reactant. To overcome the challenge, porous electrodes can be fabricated and used as a scaffold for electrochemical biosensing.

  2. (2) Semiconductor-based biosensors

    Semiconductor-based biosensors can detect the intrinsic charge of target proteins which bind specifically to receptors that are immobilized on the sensing elements’ surface that are the transistor gate or an extended gate. One important issue that affects such sensors is that protein charge detection is hampered by charge screening due to the electrical double layer at the electrolyte near the sensing surface. That double layer thickness is in the range of the solution’s Debye length. To overcome that problem, by taking the advantages of small receptors, I have succeeded in sensitive detection for influenza virus, tumor marker, hormones etc.

Representative Papers
  1. H. Hayashi, N. Sakamoto, S. Hideshima*, Y. Harada, M. Tsuna, S. Kuroiwa, K. Ohashi, T. Momma and T. Osaka*, Tetrameric jacalin as a receptor for field effect transistor biosensor to detect secretory IgA in human sweat, J. Electroanal. Chem., 873, 114371 (2020)
  2. S. Hideshima*, H. Hayashi, H. Hinou, S. Nambuya, S. Kuroiwa, T. Nakanishi, T. Momma, S.-I. Nishimura, Y. Sakoda and T. Osaka*, Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles, Sci. Rep., 9, 11616 (2019).
  3. S. Hideshima*, M. Saito, K. Fujita, Y. Harada, M. Tsuna, S. Sekiguchi, S. Kuroiwa, T. Nakanishi and T. Osaka*, Label-free detection of allergens in food via surfactant-induced signal amplification using a field effect transistor-based biosensor, Sens. Actuators, B, 254, 1011 (2018)
  4. S. Cheng, S. Hideshima, S. Kuroiwa, T. Nakanishi and T. Osaka*, Label-free detection of tumor markers using field effect transistor (FET)-based biosensors for lung cancer diagnosis, Sens. Actuators, B, 212, 329 (2015).
  5. S. Wustoni, S. Hideshima, S. Kuroiwa, T. Nakanishi, M. Hashimoto, Y. Mori and T. Osaka*, Sensitive electrical detection of human prion proteins using field effect transistor biosensor with dual-ligand binding amplification, Biosens. Bioelectron., 67, 256 (2015)
  6. S. Hideshima, M. Kobayashi, T. Wada, S. Kuroiwa, T. Nakanishi, N. Sawamura, T. Asahi and T. Osaka*, A label-free electrical assay of fibrous amyloid β based on semiconductor biosensing, Chem. Commun., 50, 3476 (2014).
  7. S. Hideshima, H. Hinou, D. Ebihara, R. Sato, S. Kuroiwa, T. Nakanishi, S.-I. Nishimura and T. Osaka*, Attomolar Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-Blotted Field Effect Transistor Biosensor, Anal. Chem., 85, 5641 (2013).
  8. S. Hideshima, R. Sato, S. Inoue, S. Kuroiwa and T. Osaka*, Detection of tumor marker in blood serum using antibody-modified field effect transistor with optimized BSA blocking, Sens. Actuators, B, 161, 146 (2012).
  9. S. Hideshima, R. Sato, S. Kuroiwa and T. Osaka*, Fabrication of stable antibody-modified field effect transistors using electrical activation of Schiff base cross-linkages for tumor marker detection, Biosens. Bioelectron., 26, 2419 (2011).
  10. S. Hideshima, H. Einati, T. Nakamura, S. Kuroiwa, Y. Shacham-Diamand and T. Osaka*, Theoretical Optimization Method of Buffer Ionic Concentration for Protein Detection Using Field Effect Transistors, J. Electrochem. Soc., 157, J410 (2010).
  1. Japanese Patent No. 5331952
  2. Japanese Patent No. 5549356
  3. Japanese Patent No. 6019944
  4. Japanese Patent No. 6277633
  5. Japanese Patent No. 6731664
Award 232nd ECS meeting sensor division Z05 symposium poster award (1st Prize) (2017)
Young Researcher Award, The foundation of Ando laboratory (2016)
Mizuno Award from Department of Applied Chemistry, Waseda University (cum laude) (2011)
Young Researcher Award, The Surface Science Society of Japan (2009)
Grant-in-Aid for Scientific Research Support: Japan Society for Promotion of Science (JSPS)
Research Grants/Projects including subsidies, donations, grants, etc. KAKENHI Grant-in-Aid for Scientific Research (C) (2020-2022)
Recruitment of research assistant(s) Yes
Affiliated academic society (Membership type) The Electrochemical Society of Japan (Member)
The Japan Society of Vacuum and Surface Science (Member)
Education Field (Undergraduate level) Applied Electrochemistry
Education Field (Graduate level) Reaction design chemistry, Adv.